Svetlana Lutsenko Selected Research

Copper-Transporting ATPases

7/2017	Targeted inactivation of copper transporter Atp7b in hepatocytes causes liver steatosis and obesity in mice.
5/2014	Modifying factors and phenotypic diversity in Wilson's disease.
3/2005	The copper-transporting ATPases, menkes and wilson disease proteins, have distinct roles in adult and developing cerebellum.
8/2004	The distinct functional properties of the nucleotide-binding domain of ATP7B, the human copper-transporting ATPase: analysis of the Wilson disease mutations E1064A, H1069Q, R1151H, and C1104F.
8/2004	Molecular modelling of the nucleotide-binding domain of Wilson's disease protein: location of the ATP-binding site, domain dynamics and potential effects of the major disease mutations.
4/2004	The N-terminal metal-binding site 2 of the Wilson's Disease Protein plays a key role in the transfer of copper from Atox1.
8/2003	The distinct roles of the N-terminal copper-binding sites in regulation of catalytic activity of the Wilson's disease protein.
4/2003	The role of the invariant His-1069 in folding and function of the Wilson's disease protein, the human copper-transporting ATPase ATP7B.
4/2003	Functional properties of the human copper-transporting ATPase ATP7B (the Wilson's disease protein) and regulation by metallochaperone Atox1.
10/2002	Human copper-transporting ATPase ATP7B (the Wilson's disease protein): biochemical properties and regulation.

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Svetlana Lutsenko Research Topics

Disease

51	Hepatolenticular Degeneration (Wilson's Disease) 01/2022 - 01/2002
7	Neoplasms (Cancer) 01/2022 - 03/2009
7	Menkes Kinky Hair Syndrome (Menkes Disease) 01/2016 - 03/2005
4	Inflammation (Inflammations) 01/2022 - 09/2009
4	Liver Diseases (Liver Disease) 07/2017 - 09/2009
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2016 - 03/2005
3	Disease Progression 05/2014 - 12/2008
3	Inborn Genetic Diseases (Disease, Hereditary) 02/2012 - 10/2002
2	Obesity 01/2019 - 07/2017
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2022
1	Non-alcoholic Fatty Liver Disease 01/2022
1	Neoplasm Metastasis (Metastasis) 01/2022
1	Infections 01/2020
1	Hypertrophy 01/2018
1	Fatty Liver 07/2017
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2016
1	Body Weight (Weight, Body) 01/2016
1	Cholestasis 09/2015
1	Liver Failure 04/2014
1	Alzheimer Disease (Alzheimer's Disease) 02/2012
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 02/2012
1	Necrosis 01/2012
1	Hypoxia (Hypoxemia) 01/2010
1	Fibrosis (Cirrhosis) 09/2009
1	Cardiomegaly (Heart Hypertrophy) 09/2009
1	Carcinoma (Carcinomatosis) 06/2009
1	Hepatocellular Carcinoma (Hepatoma) 03/2009
1	Stomach Neoplasms (Stomach Cancer) 03/2009
1	HIV Infections (HIV Infection) 01/2009
1	Nervous System Diseases (Neurological Disorders) 08/2004
1	Neurologic Manifestations (Neurological Manifestations) 10/2002

Drug/Important Bio-Agent (IBA)

59	CopperIBA 01/2022 - 01/2002
15	Proteins (Proteins, Gene)FDA Link 03/2016 - 01/2002
11	Copper-Transporting ATPasesIBA 07/2017 - 01/2002
9	Adenosine Triphosphatases (ATPase)IBA 01/2020 - 08/2002
7	Copper Transport ProteinsIBA 01/2022 - 09/2009
6	MetalsIBA 01/2022 - 04/2004
4	Cisplatin (Platino)FDA LinkGeneric 09/2009 - 03/2009
3	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 01/2022 - 07/2012
3	LipidsIBA 01/2018 - 01/2016
3	P-type ATPasesIBA 09/2015 - 01/2002
3	Messenger RNA (mRNA)IBA 05/2014 - 03/2007
2	Phosphotransferases (Kinase)IBA 10/2012 - 01/2012
2	ChloridesIBA 10/2012 - 02/2012
2	PlatinumIBA 01/2012 - 06/2009
2	EnzymesIBA 01/2010 - 12/2007
2	Ceruloplasmin (Ferroxidase)IBA 06/2009 - 03/2005
2	NucleotidesIBA 08/2004 - 08/2004
2	MetallochaperonesIBA 04/2003 - 08/2002
1	Transferrin (beta 2 Transferrin)IBA 01/2020
1	CytokinesIBA 01/2016
1	Liver X ReceptorsIBA 01/2016
1	PolymersIBA 01/2016
1	Biological ProductsIBA 01/2016
1	Sulfides (Thioethers)IBA 01/2016
1	Indicators and Reagents (Reagents)IBA 01/2016
1	Retinoid X Receptors (Retinoid X Receptor)IBA 01/2016
1	p38 Mitogen-Activated Protein KinasesIBA 01/2016
1	Oxyquinoline (8 Hydroxyquinoline)FDA Link 01/2016
1	Genetic Markers (Genetic Marker)IBA 01/2016
1	Copper-64IBA 10/2012
1	Protein SIBA 04/2012
1	PrionsIBA 02/2012
1	Membrane Proteins (Integral Membrane Proteins)IBA 09/2009
1	1,2-oleoylphosphatidylcholine (DOPC)IBA 06/2009
1	Small Interfering RNA (siRNA)IBA 06/2009
1	Pharmaceutical PreparationsIBA 03/2009
1	Trace Elements (Biometals)IBA 02/2009
1	NF-kappa B (NF-kB)IBA 01/2009
1	SodiumIBA 01/2009
1	Chelating AgentsIBA 12/2008
1	ZincIBA 12/2008
1	Oxidoreductases (Dehydrogenase)IBA 02/2006
1	Adenosine Triphosphate (ATP)IBA 08/2004
1	CationsIBA 01/2002

Therapy/Procedure

5	Therapeutics 07/2017 - 12/2008
1	Drug Therapy (Chemotherapy) 06/2009